How will I receive
treatment with ZIRABEV?

  • ZIRABEV is given by a healthcare provider as an intravenous (IV) infusion. That means you get ZIRABEV through a needle in your vein
  • If you’ve had surgery you cannot receive ZIRABEV until at least 28 days following surgery and the wound is fully healed

How often do I have
to receive ZIRABEV?

  • Depending on your specific type of cancer, you may receive ZIRABEV every 2 to 3 weeks with or without additional treatment you may be prescribed
  • If you have questions about how often you'll receive ZIRABEV, speak with your healthcare team

How long will it take?

If your ZIRABEV infusions are tolerated:

90 minutes: 1st infusion

60 minutes: 2nd infusion

30 minutes: 3rd infusion

30 minutes: Future infusions

NOTE: You always get the same dose of ZIRABEV. If your ZIRABEV infusions are tolerated, they can take as little as 30 minutes.


Metastatic Colorectal Cancer (mCRC)

  • Every 2 weeks in combination with intravenous fluorouracil-based chemotherapy

Non–Small Cell Lung Cancer (NSCLC)

  • Every 3 weeks in combination with carboplatin and paclitaxel

Recurrent Glioblastoma (GBM)

  • Every 2 weeks

Metastatic Renal Cell Carcinoma (mRCC)

  • Every 2 weeks in combination with interferon alfa

Persistent, Recurrent, or Metastatic Cervical Cancer (CC)

  • Every 3 weeks in combination with paclitaxel and cisplatin or in combination with paclitaxel and topotecan

Possible serious side effects of ZIRABEV

Everyone reacts differently to ZIRABEV therapy, so it's important to know what the side effects are.

ZIRABEV may cause serious side effects that can be life-threatening. Your doctor will stop treatment if any serious side effects occur.

Be sure to contact your healthcare team if there are any signs of these side effects.

Most serious side effects (not common, but sometimes fatal) include:

GI perforation

A hole that develops in your stomach or intestine. Symptoms include pain in your abdomen, nausea, vomiting, constipation, or fever.

Wounds that don't heal

A cut made during surgery can be slow to heal or may not fully heal. ZIRABEV should not be used for at least 28 days before or after surgery and until surgical wounds are fully healed.

Serious bleeding

This includes vomiting or coughing up blood; bleeding in the stomach, brain, or spinal cord; nosebleeds; and vaginal bleeding. If you recently coughed up blood or had serious bleeding, be sure to tell your doctor.

Discuss your ZIRABEV treatment schedule with your healthcare provider.