How will I receive
treatment with ZIRABEV?
- ZIRABEV is given by a health care provider as an intravenous (IV) infusion. That means you get ZIRABEV through a needle in your vein
- If you’ve had surgery you cannot receive ZIRABEV until at least 28 days following surgery and the wound is fully healed
How often do I have
to receive ZIRABEV?
- Depending on your specific type of cancer, you may receive ZIRABEV every 2 to 3 weeks with or without additional treatment you may be prescribed
- If you have questions about how often you'll receive ZIRABEV, speak with your health care team
How long will it take?
If your ZIRABEV infusions are tolerated:
90 minutes: 1st infusion
60 minutes: 2nd infusion
30 minutes: 3rd and future infusions
NOTE: You always get the same dosage of ZIRABEV. If your ZIRABEV infusions are tolerated, they can take as little as 30 minutes.
Metastatic Colorectal Cancer (mCRC)
- Every 2 or 3 weeks in combination with intravenous fluorouracil-based chemotherapy
Non-Small Cell Lung Cancer (NSCLC)
- Every 3 weeks in combination with carboplatin and paclitaxel
Recurrent Glioblastoma (GBM)
- Every 2 weeks
Metastatic Renal Cell Carcinoma (mRCC)
- Every 2 weeks in combination with interferon alfa
Advanced Cervical Cancer (CC)
- Every 3 weeks in combination with paclitaxel and cisplatin or in combination with paclitaxel and topotecan
Ovarian Cancer (OC)
- Advanced (stage III or IV) epithelial ovarian, fallopian tube, or primary peritoneal cancer—every 3 weeks in combination with carboplatin and paclitaxel, followed by ZIRABEV every 3 weeks as a single agent
- Platinum-resistant recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer—every 2 or 3 weeks in combination with paclitaxel, pegylated liposomal doxorubicin, or topotecan (every 1 or 3 weeks)
- Platinum-sensitive recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer—every 3 weeks in combination with carboplatin and paclitaxel or with carboplatin and gemcitabine, followed by ZIRABEV every 3 weeks as a single agent
Possible serious side effects of ZIRABEV
Everyone reacts differently to ZIRABEV therapy, so it's important to know what the side effects are.
ZIRABEV may cause serious side effects that can be life-threatening. Your doctor will stop treatment if any serious side effects occur.
Be sure to contact your health care team if there are any signs of these side effects.
Most serious side effects (not common, but sometimes fatal) include:
GI perforation and fistulae
A hole that develops in your stomach or intestine. Symptoms include pain in your abdomen, nausea, vomiting, constipation, or fever.
The development of an abnormal passageway between 2 organs (fistula). Symptoms may vary depending on location and organs involved.
Wounds that don't heal
A cut made during surgery can be slow to heal or may not fully heal. Do not undergo surgery without first discussing this potential risk with your doctor.
This includes vomiting or coughing up blood; bleeding in the stomach, brain, or spinal cord; nosebleeds; and vaginal bleeding. If you recently coughed up blood or had serious bleeding, be sure to tell your doctor.
Discuss your ZIRABEV treatment schedule with your health care provider.